Drawing from the case studies developed for Mali and South Sudan, this brief aims to synthesize key findings, commonalities, and differences in each context as it pertains to the humanitarian-development-peace nexus (HDpN) and applications to family planning, reproductive health and maternal, newborn, and child health (FP/RH/MNCH) interventions. These themes were drawn from the original HDN conceptual framework developed for MIHR by the Johns Hopkins Center for Humanitarian Health. Both Mali and South Sudan are deeply complex and fragile environments, with the caveat that such fragility is not uniform across each country. Significant themes are outlined below and summarized in a comparative table of findings for each country drawing from both the conceptual framework and the WHO Health System Building Blocks.