The Management of At-Risk Mothers and Infants (MAMI) Care Pathway (CP) is an intervention to improve the health of mothers and their infants. The current iteration of the Care Pathway, Version 3.0, was updated in 2021 and has been adapted to a number of contexts. MOMENTUM Integrated Health Resilience is working with the Government of South Sudan and other implementers to adapt and use the Care Pathway and to document lessons learned so that other countries can establish a process of their own for adapting this intervention, in particular to fragile contexts. In this webinar, we describe the Care Pathway, the process of adapting it in South Sudan, and the operations research we will conduct to better understand how the Care Pathway might be adapted in many different settings.