This report summarizes evidence about engaging local faith actors to promote uptake of COVID-19 vaccination. It is a special investigation into lessons learned from four countries: Ghana, Indonesia, Sierra Leone, and Uganda. The report explores 15 promising practices for increasing vaccine uptake through strategic engagement of faith actors. The Policy Brief, “Promising Practices for Engaging Local Faith Actors to Promote Uptake of COVID-19 Vaccination: Lessons Learned from Four Countries,” provides an 8-page synopsis of the lessons outlined in the report.