More than half of all maternal and child deaths occur in countries affected by conflict, disasters, weak governance and institutions, population displacements, and other acute and chronic shocks and stresses. In these settings, increased illness and death result from disruptions to basic health services and systems. From self-care and respectful care to supply chain management, traditional development approaches need adaptations and refinements in fragile settings to strengthen the health resilience of individuals, households, communities, and the broader health system to minimize the impact of shocks and stresses. The webinar presenters cover these issues; webinar participants submitted numerous questions and comments for discussion during the final portion of the webinar.