This guide is intended for personnel at subnational levels (for example, district, county, health facility) who are responsible for managing the integration of COVID-19 vaccination into primary health care and other routine services in lower- and middle-income countries. With a focus on reaching high priority populations, the guide and the tools it includes provide a practical co-creation process for identifying both integrated service delivery models and the changes in management responsibilities needed to support such integration. If health personnel have already adopted such practices, this guide can help refine the management practices and processes.