This evaluation framework, which includes research questions, measurement suggestions, and interpretation guidance, is meant to produce actionable evidence to guide Madagascar’s nationwide heat-stable carbetocin (HSC) expansion, which is planned for 2024 to 2026 and aims to optimize postpartum hemorrhage prevention. It may also be relevant for other ministries of health, UNFPA implementation leaders, and other entities responsible for the rollout of HSC to support similar efforts and facilitate standardized global learning about HSC.