This article was published on October 2, 2024 in the Journal Vaccines. This study used the Behavior Integration (BI) framework to identify barriers and motivators for COVID-19 vaccination in Moldova, North Macedonia, and Serbia, focusing on vaccine demand and confidence. Through qualitative interviews and quantitative surveys, the study found that vaccine safety concerns, logistical challenges, and institutional distrust were key barriers, while personal health concerns and recommendations from healthcare providers acted as motivators. Tailored strategies, such as medical provider training and patient workshops, were implemented to increase vaccine uptake, with positive results in knowledge and vaccination rates.